Senile plaques and neurofibrillary tangles: The concurrent lesions of alzheimer's disease
نویسندگان
چکیده
منابع مشابه
Senile plaques and neurofibrillary tangles in cortical neurons in AD
Neurodegenerative disorders are characterized clinically by insidious onset and slowly progressive course, and are frequently hereditary. Pathologically, these diseases share a common feature: the selective loss of a particular subset of neurons for unknown reasons [e.g. cerebral cortical neurons in ALZHEIMER’S DISEASE (AD) (see Glossary), substantia nigra neurons in PARKINSON’S DISEASE (PD), s...
متن کاملThe molecular biology of senile plaques and neurofibrillary tangles in Alzheimer's disease.
Since the earliest descriptions of the disease, senile plaques (SP) and neurofibrillary tangles (NFT) have been regarded as the pathological 'hallmarks' of Alzheimer's disease (AD). Whether or not SP and NFT are sufficient cause to explain the neurodegeneration of AD is controversial. The major molecular constituents of these lesions, viz., beta-amyloid (Ass) and tau, have played a defining rol...
متن کاملIs there a spatial association between senile plaques and neurofibrillary tangles in Alzheimer's disease?
OBJECTIVE To test the hypothesis that the clusters of senile plaques (SP) and neurofibrillary tangles (NFT) in patients with Alzheimer's disease (AD) are spatially associated as predicted by the 'Amyloid Cascade Hypothesis'. METHODS The spatial association between the SP and NFT was studied in the cerebral cortex and hippocampus in six cases of sporadic Alzheimer's disease (AD) using continge...
متن کاملAre routine methods good enough to stain senile plaques and neurofibrillary tangles in different brain regions of demented patients?
INTRODUCTION Numerous clinical cases have been reported showing the clinical picture of dementia but not meeting the neuropathological criteria for Alzheimer's dementia (AD). Different methods used to stain senile plaques (SPs) and neurofibrillary tangles (NFTs) might account for this discrepancy. SUBJECTS AND METHODS Here, brains of 11 patients with dementia were examined. Cryosections and p...
متن کاملVitamin E therapy prevents the accumulation of congophilic amyloid plaques and neurofibrillary tangles in the hippocampus in a rat model of Alzheimer’s disease
Objective(s): Vitamin E may have beneficial effects on oxidative stress and Aβ-associated reactive oxygen species production in Alzheimer’s disease. But, the exact role of vitamin E as a treatment for Alzheimer’s disease pathogenesis still needs to be studied. Hence, we examined the therapeutic effects of vitamin E on the density of congophilic amyloid plaques and neur...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 1995
ISSN: 0197-4580
DOI: 10.1016/0197-4580(94)00178-4